Vitamin B9 Monograph

Scientific name of Vitamin B9:
Folic Acid, Folate

Action of Vitamin B9:
Vital nutrient in the formation of red blood cells; aids in the formation of genetic material

Vitamin B9 is used for these functions in the body and brain:
Cognitive health; nervous system function; immune system response

Find Vitamin B9 in these Clarocet blends:

Clarocet NRI® Immediate Response Capsules™
promote fast-acting relaxation when you need it most.

Clarocet ERT® Extended Release Tablets™
promote positive mood balance all day strong.

Clarocet CS® Controlled Release Tablets™
promote long-lasting energy and mental sharpness.

Clarocet PM® Rapid Release Capsules™
promote a deep, restful night's sleep.

Clarocet Junior® Easy-to-Swallow Tablets™
support Emotional Wellness in kids ages 7 thru 13.

An Overview of Vitamin B9

B9, or Folate, is a water-soluble vitamin found in legumes, whole grains, seeds, dark leafy greens and citrus fruits. Folic Acid is the synthetic form of Vitamin B9 that is found in nutritional products and fortified foods.

Vitamin B9 supplementation has been shown to provide positive support for:

  • Cognitive health
  • Nervous system function
  • Immune system response

Folate is an essential vitamin that the body is unable to produce on its own. Therefore, it must be replenished every day through the diet and/or supplementation. Folate deficiency may result in tiredness, fatigue and weakness, depressed mood and mental confusion.

Science and Pharmacology of Vitamin B9

B9, or Folate, is a cofactor. Cofactors are the most important components required to maintain fundamental processes throughout the body. Basic nervous system functions such as neurotransmitter synthesis and healthy cell-to-cell communication would not be possible without the presence of necessary vitamin, mineral and amino acid cofactors.

Supplementing a balanced diet with Vitamin B9 has been clinically shown to promote healthy neurological function. Because of its nutritional value, Folate is used in several Clarocet formulations along with other essential vitamins, minerals and amino acids that are associated with healthy nervous system function.

Vitamin B9 Safety and Usage

Recommended Daily Allowances (RDAs) are the amounts of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex and physical condition, including considerations like pregnancy.

This chart shows the recommended daily amounts of Vitamin B9 for different groups:

Infants and children (Birth to 3  years) 50 – 80 mcg
4 to 6 years of age 75 – 400 mcg
7 to 10 years of age 100 – 400 mcg
 Adolescent and adult males 150 – 220 mcg
Adolescent and adult females 145 – 190 mcg

What are the potential side effects of Vitamin B9?

Side effects have not been reported as a result of Vitamin B9 use.

Is Vitamin B9 safe for children?

Vitamin B9 is generally well tolerated when used in children. Because each child is unique, Vitamin B9 should be administered under the supervision of a professional healthcare provider.

Does Vitamin B9 adversely interact with prescription drugs?

Vitamin B9 has no known contraindications. If you are taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to your current treatment plan.

What precautions should I take before beginning Vitamin B9?

Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like Vitamin B9.

Vitamin B9 Clinical Studies

1. Homocysteinemia in psychiatric disorders: association with dementia and depression, but not schizophrenia in female patients.
Reif A, Schneider MF, Kamolz S, Pfuhlmann B.
J Neural Transm. 2003 Dec;110(12):1401-11. Epub 2003 Oct 24.PMID: 14666412 [Read the Abstract]

2. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study.
Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ, Breteler MM.
Department of Epidemiology and Biostatistics, Erasmus Medical Centre, The Netherlands.
Am J Psychiatry. 2002 Dec;159(12):2099-101. PMID: 12450964 [Read the Abstract]

3. Folate, vitamin B12, and neuropsychiatric disorders
Bottiglieri T. Kimberly H. Courtwright and Joseph W. Summers
Institute of Metabolic Disease, Baylor University Medical Center,USA.
Nutr Rev. 1996 Dec;54(12):382-90. PMID: 9155210 [Read the Abstract]

4. The clinical potential of ademetionine (S-adenosylmethionine) in neurological disorders.
Bottiglieri T, Hyland K, Reynolds EH.
Metabolic Disease Center, Baylor Research Institute
Drugs. 1994 Aug;48(2):137-52. PMID: 7527320 [Read the Abstract]

5. Homocysteine, folate, methylation, and monoamine metabolism in depression.
Bottiglieri T, Laundy M, Crellin R, Toone BK, Carney MW, Reynolds EH.
Department of Neurology, King's College Hospital
J Neurol Neurosurg Psychiatry. 2000 Aug;69(2):228-32. PMID: 10896698 [Read the Abstract]

6. Randomized trial of folic acid supplementation and serum homocysteine levels.
Wald DS, Bishop L, Wald NJ, Law M, Hennessy E, Weir D, McPartlin J, Scott J.
Department of Cardiology, St Richard's Hospital, England.
Arch Intern Med. 2001 Mar 12;161(5):695-700. PMID: 11231701 [Read the Abstract]

7.Folic Acid (Vitamin B 9) (Systemic)
National Library of Medicine, Micromedex, Pharmacopeia Drug Information, Volume II
Medline Plus; Rev.:Dec. 30, 1999 [Read the Abstract]

Related online research destinations

Last Updated: February 2015 [PHMF-03-0]