Vitamin B3 Monograph

Scientific name of Vitamin B3:
Niaicin

Action of Vitamin B3:
Energy production; vital component for Acetylcholine production

Vitamin B3 is used for these functions in the body and brain:
Neurological health; nervous system function; energy metabolism

Find Vitamin B3 in these Clarocet blends:

Clarocet NRI® Immediate Response Capsules™
promote fast-acting relaxation when you need it most.

Clarocet ERT® Extended Release Tablets™
promote positive mood balance all day strong.

Clarocet CS® Controlled Release Tablets™
promote long-lasting energy and mental sharpness.

Clarocet PM® Rapid Release Capsules™
promote a deep, restful night's sleep.

Clarocet Junior® Easy-to-Swallow Tablets™
support Emotional Wellness in kids ages 7 thru 13.

An Overview of Vitamin B3

B3, or Niacin, is a water-soluble vitamin that occurs naturally in plant tissues. Good sources of Niacin include nuts, legumes, leafy green vegetables, whole-grain breads and cereals.

Vitamin B3 supplementation has been shown to provide positive support for:

  • Emotional stress
  • Elevated cortisol levels
  • Transportation of important molecules across the blood-brain barrier

Niacin is an essential vitamin that the body is unable to produce on its own. Therefore, it must be replenished everyday through the diet and/or supplementation. Niacin deficiency may result in irritability, loss of appetite, weakness, mental confusion and dizziness.

Science and Pharmacology of Vitamin B3

B3, or Niacin, is a cofactor. Cofactors are the most important components required to maintain fundamental processes throughout the body. Basic nervous system functions such as neurotransmitter synthesis and healthy cell-to-cell communication would not be possible without the presence of necessary vitamin, mineral and amino acid cofactors.

Supplementing a balanced diet with Vitamin B3 has been clinically shown to promote normal cell function and energy metabolism. Because of its nutritive value, Niacin is used in several Clarocet formulations along with other essential vitamins, minerals and amino acids that are associated with healthy nervous system function.

Vitamin B3 Safety and Usage

Recommended Daily Allowances (RDAs) are the amounts of vitamins and minerals needed to provide for adequate nutrition in most healthy persons. RDAs for a given nutrient may vary depending on a person’s age, sex and physical condition, including considerations like pregnancy.

This chart shows the recommended daily amounts of Vitamin B3 for different groups:

Infants and children (Birth to 3  years) 5 – 9 mg
4 to 6 years of age 12 mg
7 to 10 years of age 13 mg
 Adolescent and adult males 15 – 20 mg
Adolescent and adult females 13 – 15 mg
Pregnant females 17 mg
Breastfeeding females 20 mg

What are the potential side effects of Vitamin B3?

Side effects have not been reported as a result of Vitamin B3 use.

Is Vitamin B3 safe for children?

Vitamin B3 is generally well tolerated when used in children. Because each child is unique, Vitamin B3 should be administered under the supervision of a professional healthcare provider.

Does Vitamin B3 adversely interact with prescription drugs?

Vitamin B3 has no known contraindications. If you are taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to your current treatment plan.

What precautions should I take before beginning Vitamin B3?

Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like Vitamin B3.

Vitamin B3 Clinical Studies

1. Sustained-release niacin for prevention of migraine headache.
Velling DA, Dodick DW, Muir JJ.
Division of Pain Management Mayo Clinic, Scottsdale, Ariz 85259, USA.
Mayo Clin Proc. 2003 Jun;78(6):770-1. PMID: 12934790 [Read the Abstract ]

2. Hypothesized treatment for migraines using low doses of tryptophan, niacin, calcium, caffeine, and acetylsalicylic acid.
Gedye A.
Med Hypotheses. 2001 Jan;56(1):91-4. PMID: 11133261 [Read the Abstract ]

3. Tryptophan-nicotinamide, imipramine and their combination in depression. A controlled study.
Chouinard G, Young SN, Annable L, Sourkes TL.
Acta Psychiatr Scand. 1979 Apr;59(4):395-414. PMID: 155389 [Read the Abstract]

4. Niacin (Vitamin B 3) (Systemic)
National Library of Medicine, Micromedex, Pharmacopeia Drug Information, Volume II
Medline Plus; Rev.:June 06, 2003 [Read the Full Text ]

5. Nutritional Approach to Mental Health
Dr. Hyla Cass, MD Centre for Wellness
Canadian Mental Health Association
Rev.: Aug. 30, 2002 [Read the Article]

Related online research destinations

Last Updated: February 2015 [PHMF-03-0]