Inositol Monograph

Scientific name of Inositol:

Action of Inositol:
Supports healthy nervous system function

Inositol is used for these common wellness concerns:
Mild mood changes and occasional anxiety caused by everyday stress

Find Inositol in these Clarocet blends:

An Overview of Inositol

Inositol is an important nutritional compound that regulates cellular functions and enzyme activity. Common food sources include vegetables, bananas, brown rice, wheat germ, nuts, unrefined molasses and raisins.

Inositol supplementation has been shown to provide positive support for:

  • Mild mood changes
  • Occasional anxiety caused by everday stress

Inositol is produced in small amounts by the body. Although deficiencies are rare, exposure to environmental toxins and other external stressors may increase the rate at which Inositol is depleted in the body. Inositol deficiency may be a contributing factor in memory loss, anxiety, eczema, hair loss and constipation.

Science and Pharmacology of Inositol

Inositol is a cofactor. Cofactors are the most important components required to maintain fundamental processes throughout the body. Basic nervous system functions such as neurotransmitter synthesis and healthy cell-to-cell communication would not be possible without the presence of necessary vitamin, mineral and amino acid cofactors.

Supplementing a balanced diet with Inositol has been clinically shown to relieve mild mood shifts and occasional anxiety caused by stress. Because of its nutritive value, Inositol works best when used along with other essential vitamins, minerals and amino acids that promote healthy sleep function.

Inositol Safety and Usage

Inositol maintains an excellent safety profile. No Recommended Daily Allowance (RDA) exists for Inositol because it is a nonessential nutrient. Adults are advised to take between 250 and 1000 milligrams to provide positive support for low energy levels and mental fatigue caused by occasional anxiety and stress.

What are the potential side effects of Inositol?

Side effects are rare and have been documented as mild in clinical study. They may include gastrointestinal discomfort. In the event that you or your child experiences an adverse reaction, discontinue use of this dietary supplement.

Is Inositol safe for children?

Inositol is well tolerated when used in children. Because each child is unique, Inositol should be administered under the supervision of a professional healthcare provider.

Does Inositol adversely interact with prescription drugs?

Inositol has no known contraindications. If you or your child is taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to a current treatment plan.

What precautions should I take before beginning Inositol?

Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like Inositol.

Inositol Clinical Studies

1. Inositol - Clinical Applications for Exogenous Use
Lisa Colodny, Pharm D. and Rolnald L. Hoffman, M.D.
Thorne Research, Inc., USA
Alt Med Rev 1998;3(6):432-447 [Read the Review]

2. Inositol treatment raises CSF inositol levels.
Levine J, Rapaport A, Lev L, Bersudsky Y, Kofman O, Belmaker RH, Shapiro J, Agam G.
Abarbanel Mental Health Center, Bat Yam, Israel.
Brain Res. 1993 Nov 5;627(1):168-70. PMID: 8293297 [Read the Abstract]

3. Effects of myo-inositol versus fluoxetine and imipramine pretreatments on serotonin 5HT2A and muscarinic acetylcholine receptors in human neuroblastoma cells.
Brink CB, Viljoen SL, de Kock SE, Stein DJ, Harvey BH.
Division of Pharmacology, Potchefstroom Campus of the North-West University, South Africa.
Metab Brain Dis. 2004 Jun;19(1-2):51-70. PMID: 15214506 [Read the Abstract]

4. Myo-Inositol: Overview of Actions, Pharmacology, Mechanisms, Dosage and Safety
Thomson Healthcare
PDRHealth 2005 [Read the Review]

5. Chronic epi-inositol has an anxiolytic-like effect in the plus-maze model in rats.
Einat H, Elkabaz-Shwortz Z, Cohen H, Kofman O, Belmaker RH.
Faculty of Health Sciences, Ben Gurion University of the Negev, Israel.
Int J Neuropsychopharmacol. 1998 Jul;1(1):31-34. PMID: 11281942 [Read the Abstract]

6. High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium.
Agam G, Shapiro Y, Bersudsky Y, Kofman O, Belmaker RH.
Laboratory of Biochemistry, Soroka Medical Center, Beer-Sheva, Israel.
Pharmacol Biochem Behav. 1994 Oct;49(2):341-3. PMID: 7824547 [Read the Abstract]

7. Inositol versus placebo augmentation of serotonin reuptake inhibitors in the treatment of obsessive-compulsive disorder: a double-blind cross-over study.
Fux M, Benjamin J, Belmaker RH.
Ministry of Health Mental Health Center, Faculty of Health Sciences, Israel.
Int J Neuropsychopharmacol. 1999 Sep;2(3):193-195. PMID: 11281989 [Read the Abstract]

8. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder.
Palatnik A, Frolov K, Fux M, Benjamin J.
Ministry of Health Mental Health Center, Faculty of Health Sciences, Israel.
J Clin Psychopharmacol. 2001 Jun;21(3):335-9. PMID: 11386498 [Read the Abstract]

9. Double-blind, controlled trial of inositol treatment of depression.
Levine J, Barak Y, Gonzalves M, Szor H, Elizur A, Kofman O, Belmaker RH.
Yehuda Abarbanel Mental Health Center, Israel.
Am J Psychiatry. 1995 May;152(5):792-4. PMID: 7726322 [Read the Abstract]

Related online research destinations

Last Updated: February 2015 [PHMF-03-0]