Arctic Root Monograph

Scientific name of Rhodiola Rosea::
Rhodiola Rosea

Action of Rhodiola Rosea:
Promotes healthy emotional and neurological function

Rhodiola Rosea is used for these common wellness concerns:
A lack of focus or mental clarity, decrease mental performance, and mental or physical fatigue caused by everyday stress; occasional anxiety; mood changes and a depressed mood caused by everyday stress

Find Arctic Root in these Clarocet blends:

An Overview of Arctic Root

Arctic Root is a plant indigenous to Siberia, where it thrives in high altitudes and dry arctic climate. The primary medicinal compounds of Arctic Root are derived from the root of the plant.
In Russia, Scandinavia and much of Europe, Arctic Root has been traditionally recognized for its adaptogenic properties. An adaptogen is a physiological agent that naturally increases the body’s resistance to physical and emotional stress. Modern research indicates that the active components of Arctic Root provide positive support for:

  • Focus, attention span, concentration, memory, mental sharpness and other healthy cognitive functions
  • Mental and physical fatigue caused by emotional stress
  • Depressed mood and mild to moderate mood changes caused by everyday stress
  • Occasional nervousness, nervous tension and anxiety
  • Reduced immune system response caused by physical and emotional stressors

Rhodiola Rosea has been clinically shown to stimulate Serotonin, Norepinephrine and Dopamine activity, and may help to support healthy neurotransmitter balance.

Science and Pharmacology of Arctic Root

Laboratory studies have isolated specific phytochemical components from the root of Arctic Root. Arctic Root’s broad spectrum of action is thought to be caused the following compounds:

  • Rosavin
  • Rosarin
  • Salidrosides
  • Tyrosol

Arctic Root has been identified in clinical analysis as an adaptogen, which means it increases the body’s resistance to a wide range of chemical, biological and physical stressors. Scientists explain that Arctic Root likely affects multiple body systems to promote emotional wellbeing, physical endurance and mental sharpness.

Pharmacological studies have demonstrated that Arctic Root stimulates neurotransmitter activity in the central nervous system, and itmay positively influence Serotonin, Norepinephrine, Dopamine and Acetylcholine availability in neuropathways that regulate mood. Further laboratory analysis has shown that Arctic Root also enhances permeability of the blood-brain barrier to specific neurotransmitter precursors of Serotonin and Dopamine.

Although the exact mechanisms of action are not yet fully understood, clinical and laboratory research indicate that Arctic Root may help to promote healthy neurotransmitter balance and provide positive support for occasional nervousness, nervous tension and anxiety, as well as depressed mood and mild to moderate mood changes caused by everyday stress.

Arctic Root Safety and Usage

Arctic Root maintains an excellent safety profile when it is used as directed. A dose of 100 to 300 milligrams is recommended to promote healthy cognitive functions such as focus, attention, concentration, memory and mental sharpness. The same dose is also recommended to relieve occasional nervousness, nervous tension, anxiety or depressed mood caused by everyday stress.

What are the potential side effects of Arctic Root?

Side effects are rare and have been documented as mild to moderate in clinical study. They may include headache, gastrointestinal discomfort, drowsiness, dizziness or sleep difficulty. In the event that you experience an adverse reaction, discontinue use of this herb. Arctic Root does not cause withdrawal or discontinuation effects.

Is Arctic Root safe for children?

Clinical study data regarding Arctic Root use in children is limited. Arctic Root should not be administered without the supervision of a professional healthcare provider.

Does Arctic Root adversely interact with prescription drugs?

Taking Arctic Root in combination with prescription medications such as benzodiazepines, SSRIs (selective serotonin reuptake inhibitors), or SNRIs (serotonin-norepinephrine reuptake inhibitors) may cause drowsiness. If you are taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to your current treatment plan.

What precautions should I take before beginning Arctic Root?

Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like Arctic Root.

  • Do not take Arctic Root if you are pregnant or nursing
  • Do not take Arctic Root if you are currently taking a prescription MAOI
  • Do not take Arctic Root if you are currently taking a protease inhibitor for HIV/AIDS
  • Do not operate vehicles or heavy machinery until you know how Arctic Root affects you

Arctic Root Clinical Studies

1. Rhodiola Rosea: A Phytomedicinal Overview
Richard P. Brown, M.D., Patricia L. Gerbarg, M.D., Zakir Ramazanov,Ph.D.
American Botanical Council
Herbalgram. 2002;56:40-52 [Read The Full Text]

2. Experimental analysis of therapeutic properties of Rhodiola rosea L. and its possible application in medicine
Kucinskaite A, Briedis V, Savickas A.
Department of Pharmaceutical Technology and Pharmacy Organization, Kaunas University of Medicine
Medicina (Kaunas). 2004;40(7):614-9. PMID: 15252224 [Read The Abstract]

3. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles.
Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T.
Institute of Immunopathology, Russian Academy of Natural Sciences, Moscow.
Bull Exp Biol Med. 2003 Dec;136(6):585-7. PMID: 15500079 [Read The Abstract]

4. In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes.
De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchiarini L, Dacha M.
Istituto di Chimica Biologica "Giorgio Fornaini", Universita degli Studi di Urbino "Carlo Bo", Urbino (PU), Italy.
Biofactors. 2004;20(3):147-59. PMID: 15665385 [Read The Abstract]

5. Therapy of Asthenic Conditions: Clinical Perspectives of Application of Rhodiola Rosea extract
Krasik ED, Morozova ES, Petrova KP, et. al.
Russian Acadamy of Sciences
Proceedings Modern Problems in Psycho-Pharmacology. 1970;298-330

6. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen.
Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV.
Volgograd Medical Academy, Russia.
Phytomedicine. 2000 Apr;7(2):85-9. PMID: 10839209 [Read The Abstract]

7. The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load
Spasov AA, Mandrikov VB, Mironova IA.
Volgograd State Medical Academy, Ministry of Public Health of the Russian Federation, Russia.
Eksp Klin Farmakol. 2000 Jan-Feb;63(1):76-8. PMID: 10763116 [Read The Abstract]

8. Alternative Therapies in Psychiatry.
Brown RP, Gerbarg PG, Muskin PR.
Tasman A, Lieberman J, Kay J, editors. Psychiatry. 2nd ed.
West Sussex, England: Wiley & Sons, Ltd.; 2002.

9. Rhodiola rosea in stress induced fatigue: a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty.
Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H.
Department of Neurology, Armenian State Medical University
Phytomedicine 2000;7(5):365-71. [Read The Abstract]

10. Rhodiola Rosea is a Valuable Medicinal Plant (Golden Root)
Saratikov AS, Krasnov EA
Tomsk, Russia
Tomsk State University Press; 1987

11. Chemical Composition of Rhodiola Rosea
Saratikov AS, Krasnov EA
Tomsk, Russia
Tomsk State University Press. 1987;1: 3-39

12. Changes in the Brain Biogenic Monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine
Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV
Gen. Pharmacol. 1990;21(1):71-5

13. Effects of meclofenoxate and extr. Rhodiolae rosea L. on electroconvulsive shock-impaired learning and memory in rats.
Lazarova MB, Petkov VD, Markovska VL, Petkov VV, Mosharrof A.
Methods Find Exp Clin Pharmacol. 1986;8(9):547-52.

14. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory.
Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, et al.
Acta Physiol Pharmacol Bulg 1986;12(1):3-16.

15. Effect of golden root extract on processes of serotonin synthesis in CNS.
Saratikov A, Marina TF, Fisanova LL.
Journal of Biological Sciences 1978;6:142.

16. Effect of Rhodiola rosea extract on electroencephalograms in rabbit.
Marina TF, Alekseeva LP. Saratikov AS
Tomsk, Russia:
Stimulants of the Central Nervous System. Tomsk State University Press; 1968. p. 22-6.

17. Effect of Rhodiola rosea extract on bioelectrical activity of the cerebral cortex isolated to a different extent from the brain.
Marina TF, Saratikov AS
Stimulants of the Central Nervous System. Tomsk State University Press; 1968. p. 27-31.

18. Rhodiola rosea: a possible plant adaptogen.
Kelly GS
Thorne Research
Altern Med Rev. 2001 Jun;6(3):293-302. PMID: 11410073  [Read The Abstract]

19. Effect of several stimulators on central nervous system energy metabolism during muscular workload
Salnik BU.
Tomsk, Russia: Tomsk State Medical Institute; 1970.

20. Effect of extracts from Rhodiola rosea and Rhodiola crenulata roots on ATP content in mitochondria of skeletal muscles.
Abidov M, Crendal F, Grachev S, Seifulla R, Ziegenfuss T.
Institute of Immunopathology, Russian Academy of Natural Sciences, Moscow.
Bull Exp Biol Med. 2003 Dec;136(6):585-7. PMID: 15500079 [Read The Abstract]

21. Effects of Rhodiola on the process of energetic recovery of rat under intense muscular workload
Adamchuk LB.
Tomsk, Russia: Tomsk State Medical Institute; 1969.

22. In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes.
De Sanctis R, De Bellis R, Scesa C, Mancini U, Cucchiarini L, Dacha M.
Istituto di Chimica Biologica Giorgio Fornaini, Universita degli Studi di Urbino, Urbino, Italy.
Biofactors. 2004;20(3):147-59. PMID: 15665385 [Read The Abstract]

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Last Updated: February 2015 [PHMF-03-0]