ALC Monograph

Common Names for ALC ::
Acetyl-L-Carnitine, Carnitine

Action of ALC:
Supports a healthy neurotransmitter balance and energy production

ALC is used for these common wellness concerns:
A decrease in mental performance and memory function caused by everyday stress

Find ALC in these Clarocet blends:

An Overview of ALC

Acetyl-L-Carnitine (ALC) is a naturally occurring compound primarily used for energy production in the body. Common food sources include vegetables, grains, lamb and beef.
ALC supplementation has been shown to provide positive support for:

  • Mental performance
  • Memory maintenance
  • Synthesis of the neurotransmitter acetylcholine

Acetyl-L-Carnitine is produced in small amounts by the body. Although deficiencies are rare, vegetarians may be at risk because their diets often lack adequate sources of Acetyl-L-Carnitine. An ALC deficiency can result in muscle fatigue, cramping, tiredness and heart irregularities.

Science and Pharmacology of ALC

Acetyl-L-Carnitine is a cofactor. Cofactors are the vital components required to maintain fundamental processes throughout the body. Basic nervous system functions, such as neurotransmitter synthesis and healthy cell-to-cell communication, would not be possible without the presence of necessary vitamin, mineral and amino acid cofactors.

Supplementing a balanced diet with Acetyl-L-Carnitine has been clinically shown to stimulate energy metabolism and to support cognitive functions such as mental performance and memory maintenance. Because of its nutritive value, ALC is best used along with other essential vitamins, minerals and amino acids that promote healthy neurological function.

ALC Safety and Usage

Acetyl-L-Carnitine maintains an excellent safety profile. No Recommended Daily Allowance (RDA) exists for Acetyl-L-Carnitine because it is a nonessential nutrient. Adults are advised to take between 10 and 100 milligrams to promote healthy cognitive functions such as mental performance and memory maintenance. A dose of 10 to 40 milligrams is recommended for children between the ages of seven and 13.

What are the potential side effects of ALC?

Side effects are rare and have been documented as mild in clinical studies. They may include gastrointestinal discomfort. In the event that you or your child experiences an adverse reaction, discontinue use of this dietary supplement.

Is ALC safe for children?

Acetyl-L-Carnitine is generally well tolerated when used in children. Because each child is unique, Acetyl-L-Carnitine should be administered under the supervision of a professional healthcare provider.

Does ALC adversely interact with prescription drugs?

Acetyl-L-Carnitine has no known contraindications. If you or your child is taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to a current treatment plan.

What precautions should I take before beginning ALC?

Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like Acetyl-L-Carnitine.

ALC Clinical Studies

1. Acetyl-L-Carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach.
Brooks JO 3rd, Yesavage JA, Carta A, Bravi D.
Stanford University School of Medicine, California, USA.
Int Psychogeriatr. 1998 Jun;10(2):193-203. PMID: 9677506 [Read the Abstract]

2. Acetyl-L-carnitine in Alzheimer disease: a short-term study on CSF neurotransmitters and neuropeptides.
Bruno G, Scaccianoce S, Bonamini M, Patacchioli FR, Cesarino F, Grassini P, Sorrentino E, Angelucci L, Lenzi GL.
Dipartimento di Scienze Neurologiche, Universita di Roma La Sapienza, Italy.
Alzheimer Dis Assoc Disord. 1995 Fall;9(3):128-31. PMID: 8534410 [Read the Abstract]

3. L-acetylcarnitine treatment of mental decline in the elderly.
Salvioli G, Neri M.
Institute of Gerontology and Geriatrics, Estense Hospital, University of Modena, Italy.
Drugs Exp Clin Res. 1994;20(4):169-76. PMID: 7813389 [Read the Abstract]

4. Acetyl-L-carnitine as a precursor of acetylcholine.
White HL, Scates PW.
Division of Pharmacology, Wellcome Research Laboratories, USA
Neurochem Res. 1990 Jun;15(6):597-601. PMID: 2215852 [Read the Abstract]

5. The dopamine theory of attention deficit hyperactivity disorder (ADHD).
Levy F.
Department of Child and Adolescent Psychiatry, University of New South Wales, Randwick.
Aust N Z J Psychiatry. 1991 Jun;25(2):277-83. PMID: 1652243 [Read the Abstract]

6. Effect of acetyl-L-carnitine on the dopaminergic system in aging brain.
Sershen H, Harsing LG Jr, Banay-Schwartz M, Hashim A, Ramacci MT, Lajtha A.
Center for Neurochemistry, Nathan S. Kline Institute for Psychiatric Research, USA
J Neurosci Res. 1991 Nov;30(3):555-9. PMID: 1839317 [Read the Abstract]

7. Effects of long-term acetyl-L-carnitine administration in rats: I. increased dopamine output in mesocorticolimbic areas and protection toward acute stress exposure.
Tolu P, Masi F, Leggio B, Scheggi S, Tagliamonte A, De Montis MG, Gambarana C.
Department of Neuroscience, Pharmacology Unit, University of Siena, Italy.
Neuropsychopharmacology. 2002 Sep;27(3):410-20. PMID: 12225698 [Read the Abstract]

8. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome.
Vermeulen RC, Scholte HR.
Research Center Amsterdam, Amsterdam, Netherlands
Psychosom Med. 2004 Mar-Apr;66(2):276-82. PMID: 15039515 [Read the Abstract]

9. Acetyl- l-carnitine reduces impulsive behaviour in adolescent rats.
Adriani W, Rea M, Baviera M, Invernizzi W, Carli M, Ghirardi O, Caprioli A, Laviola G.
Behavioural Neuroscience Section, Dept. Cell Biology & Neurosciences, Istituto Superiore di Sanita, Italy
Psychopharmacology (Berl). 2004 May 8 PMID: 15138763 [Read the Abstract]

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Last Updated: February 2015 [PHMF-03-0]