DMAE Monograph

Scientific name of DMAE:
2-Dimethylaminoethanol

Action of DMAE:
Supports healthy neurological function

DMAE is used for these common wellness concerns:
Problems with attention span, focus, memory and other healthy cognitive functions; mild mood changes caused by everyday stress

Find DMAE in these Clarocet blends:

Clarocet NRI® Immediate Response Capsules™
promote fast-acting relaxation when you need it most.

Clarocet ERT® Extended Release Tablets™
promote positive mood balance all day strong.

Clarocet CS® Controlled Release Tablets™
promote long-lasting energy and mental sharpness.

Clarocet PM® Rapid Release Capsules™
promote a deep, restful night's sleep.

Clarocet Junior® Easy-to-Swallow Tablets™
support Emotional Wellness in kids ages 7 thru 13.

An Overview of DMAE

DMAE (2-Dimethylaminoethanol) is an organic compound related to Choline. In the brain, DMAE acts as a building block for the neurotransmitter Acetylcholine. Common food sources of DMAE include anchovies, sardines and other fish.

Clinical research shows that DMAE taken as a dietary supplement may help to provide positive support for:

  • Healthy nervous system function
  • Healthy cognitive functions such as alertness, concentration and memory
  • Normal respiratory function

DMAE is considered to be a nonessential nutrient. However, dietary supplementation with DMAE can increase natural levels of Choline, an important physiological agent that the body is unable to produce on its own. Therefore, DMAE should be replenished every day through the diet or through dietary supplementation.

Science and Pharmacology of DMAE

DMAE is a cofactor. Cofactors are the most important components required to maintain fundamental processes throughout the body. Basic nervous system functions such as neurotransmitter synthesis and healthy cell-to-cell communication would not be possible without the presence of necessary vitamin, mineral and amino acid cofactors.

Supplementing a balanced diet with DMAE has been clinically shown to support physical performance and to promote alertness, concentration, memory and other healthy cognitive functions. Because of its nutritive value, DMAE works best when used along with other essential vitamins, minerals and amino acids that promote healthy neurological function.

DMAE Safety and Usage

DMAE maintains an excellent safety profile. No Recommended Daily Allowance (RDA) exists for DMAE because it is a nonessential nutrient. A dose of 100 to 500 milligrams is recommended daily for adults if DMAE is taken alone. If DMAE is taken as part of a nutritional-herbal complex, 25 to 100 milligrams is a sufficient dose for promoting healthy nervous system function, positive mood balance and healthy cognitive functions such as attention span, focus and memory.

What are the potential side effects of DMAE?

Side effects are rare and have been documented as mild in clinical study. They may include gastrointestinal discomfort. In the event that you experience an adverse reaction, discontinue use of this dietary supplement.

Is DMAE safe for children?

DMAE is generally well tolerated when used in children. Because each child is unique, DMAE should be administered under the supervision of a professional healthcare provider.

Does DMAE adversely interact with prescription drugs?

DMAE has no known contraindications. If you are taking a prescription medication, it is recommended that you consult with your prescribing doctor before making any changes or additions to your current treatment plan.

What precautions should I take before beginning DMAE?

Consult with your healthcare provider before beginning a wellness plan that includes dietary supplements like DMAE.

DMAE Clinical Studies

1. Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states.
Dimpfel W, Wedekind W, Keplinger I.
Pro Science, Private Research Clinic GmbH - med. Forschung und Entwicklung, Germany
Eur J Med Res. 2003 May 30;8(5):183-91. PMID: 12844472 [Read the Abstract]

2. Source density analysis of functional topographical EEG: monitoring of cognitive drug action.
Dimpfel W, Hofmann HC, Prohaska A, Schober F, Schellenberg R.
Pro Science Private Research Institute GmbH, Germany
Eur J Med Res. 1996 Mar 19;1(6):283-90 PMID: 9367941 [Read the Abstract]

3. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise.
Pieralisi G, Ripari P, Vecchiet L.
Institute of Medical Pathophysiology, University of Chieti, Italy.
Clin Ther. 1991 May-Jun;13(3):373-82. PMID: 1954639 [Read the Abstract]

4. Deanol affects choline metabolism in peripheral tissues of mice.
Haubrich DR, Gerber NH, Pflueger AB.
J Neurochem. 1981 Aug;37(2):476-82 PMID: 7264671 [Read the Abstract]

Related online research destinations

Last Updated: February 2015 [PHMF-03-0]